%P 3404-3408
%A W.-N. Tan
%A Z.-H. Tan
%A N.I. Zulkifli
%A N.N.S. Nik Mohamed Kamal
%A N.A.S. Rozman
%A W.-Y. Tong
%A C.-R. Leong
%A J.-W. Lim
%I Taylor and Francis Ltd.
%V 34
%T Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities
%J Natural Product Research
%L scholars13693
%O cited By 10
%N 23
%R 10.1080/14786419.2019.1569012
%D 2020
%K caryophyllene; copaene; essential oil; germacrene D; sesquiterpene; alpha-copaene; antiinfective agent; essential oil; sesquiterpene, antimicrobial activity; antiproliferative activity; Article; Bacillus subtilis; capillary gas chromatography; chemical composition; controlled study; drug cytotoxicity; drug identification; drug structure; Garcinia; Garcinia celebica; Gram negative bacterium; Gram positive bacterium; human; human cell; hydrodistillation; IC50; in vitro study; mass fragmentography; MCF-7 cell line; MTT assay; nonhuman; plant leaf; Proteus mirabilis; cell proliferation; chemistry; drug effect; fungus; Garcinia; Malaysia; microbial sensitivity test; preclinical study, Anti-Infective Agents; Cell Proliferation; Drug Evaluation, Preclinical; Fungi; Garcinia; Gas Chromatography-Mass Spectrometry; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Malaysia; MCF-7 Cells; Microbial Sensitivity Tests; Oils, Volatile; Plant Leaves; Sesquiterpenes; Sesquiterpenes, Germacrane
%X Garcinia celebica L., locally known as �manggis hutan� in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25), germacrene D (6.72) and β-caryophyllene (5.85). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested. © 2019 Informa UK Limited, trading as Taylor & Francis Group.