TY  - JOUR
VL  - 34
JF  - Natural Product Research
A1  - Tan, W.-N.
A1  - Tan, Z.-H.
A1  - Zulkifli, N.I.
A1  - Nik Mohamed Kamal, N.N.S.
A1  - Rozman, N.A.S.
A1  - Tong, W.-Y.
A1  - Leong, C.-R.
A1  - Lim, J.-W.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096982877&doi=10.1080%2f14786419.2019.1569012&partnerID=40&md5=528952d004625fba276e42546e6a835e
Y1  - 2020///
ID  - scholars13693
KW  - caryophyllene; copaene; essential oil; germacrene D; sesquiterpene; alpha-copaene; antiinfective agent; essential oil; sesquiterpene
KW  -  antimicrobial activity; antiproliferative activity; Article; Bacillus subtilis; capillary gas chromatography; chemical composition; controlled study; drug cytotoxicity; drug identification; drug structure; Garcinia; Garcinia celebica; Gram negative bacterium; Gram positive bacterium; human; human cell; hydrodistillation; IC50; in vitro study; mass fragmentography; MCF-7 cell line; MTT assay; nonhuman; plant leaf; Proteus mirabilis; cell proliferation; chemistry; drug effect; fungus; Garcinia; Malaysia; microbial sensitivity test; preclinical study
KW  -  Anti-Infective Agents; Cell Proliferation; Drug Evaluation
KW  -  Preclinical; Fungi; Garcinia; Gas Chromatography-Mass Spectrometry; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Malaysia; MCF-7 Cells; Microbial Sensitivity Tests; Oils
KW  -  Volatile; Plant Leaves; Sesquiterpenes; Sesquiterpenes
KW  -  Germacrane
N2  - Garcinia celebica L., locally known as â??manggis hutanâ?? in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25), germacrene D (6.72) and β-caryophyllene (5.85). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
IS  - 23
EP  - 3408
PB  - Taylor and Francis Ltd.
SN  - 14786419
SP  - 3404
TI  - Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities
N1  - cited By 10
AV  - none
ER  -