relation: https://khub.utp.edu.my/scholars/13693/
title: Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities
creator: Tan, W.-N.
creator: Tan, Z.-H.
creator: Zulkifli, N.I.
creator: Nik Mohamed Kamal, N.N.S.
creator: Rozman, N.A.S.
creator: Tong, W.-Y.
creator: Leong, C.-R.
creator: Lim, J.-W.
description: Garcinia celebica L., locally known as �manggis hutan� in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25), germacrene D (6.72) and β-caryophyllene (5.85). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
publisher: Taylor and Francis Ltd.
date: 2020
type: Article
type: PeerReviewed
identifier:   Tan, W.-N. and Tan, Z.-H. and Zulkifli, N.I. and Nik Mohamed Kamal, N.N.S. and Rozman, N.A.S. and Tong, W.-Y. and Leong, C.-R. and Lim, J.-W.  (2020) Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities.  Natural Product Research, 34 (23).  pp. 3404-3408.  ISSN 14786419     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096982877&doi=10.1080%2f14786419.2019.1569012&partnerID=40&md5=528952d004625fba276e42546e6a835e
relation: 10.1080/14786419.2019.1569012
identifier: 10.1080/14786419.2019.1569012