eprintid: 13298 rev_number: 2 eprint_status: archive userid: 1 dir: disk0/00/01/32/98 datestamp: 2023-11-10 03:27:51 lastmod: 2023-11-10 03:27:51 status_changed: 2023-11-10 01:50:49 type: article metadata_visibility: show creators_name: Chai, Y.H. creators_name: Yusup, S. creators_name: Ruslan, M.S.H. creators_name: Chin, B.L.F. title: Supercritical fluid extraction and solubilization of Carica papaya linn. leaves in ternary system with CO2 + ethanol solvents ispublished: pub keywords: Carbon dioxide; Effluent treatment; Ethanol; Solubility; Supercritical fluid extraction; Supercritical fluids, Carica papaya; Experimental solubility datum; Extract yields; Operating parameters; Optimized parameter; Response surface methodology; Solubility models; Solvent flow rate, Organic solvents note: cited By 15 abstract: The supercritical fluid extraction of Carica papaya linn. leaves in the presence of CO2 solvent and ethanol modifier was carried out with respect to four operating parameters, namely temperature (40�60 °C), pressure (18�30 MPa), solvent flow rate (3�6 mL/min) and co-solvent ratio (3 � 5 vol), for the maximization of global extract yield of Carica papaya linn. leaves. The optimized parameters obtained are as follows: temperature of 57.47 °C, pressure of 26.62 MPa, solvent flow rate of 5.43 mL/min and co-solvent ratio of 4.98 with a predicted global extract yield of 0.0806 g. Five density-based solubility models, namely Chrastil, Bian et al., Bartle et al., Sparks et al. and Méndez-Santiago and Teja models were correlated against experimental solubility data. The Méndez-Santiago and Teja model were found to be more accurate with AARD of 1.36 and R2 value of 0.873 due to the non-linearity extraction profiles of papaya leaves. © 2020 date: 2020 publisher: Institution of Chemical Engineers official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078858842&doi=10.1016%2fj.cherd.2020.01.025&partnerID=40&md5=3d572fccd04ef5ac07c2635311c3069d id_number: 10.1016/j.cherd.2020.01.025 full_text_status: none publication: Chemical Engineering Research and Design volume: 156 pagerange: 31-42 refereed: TRUE issn: 02638762 citation: Chai, Y.H. and Yusup, S. and Ruslan, M.S.H. and Chin, B.L.F. (2020) Supercritical fluid extraction and solubilization of Carica papaya linn. leaves in ternary system with CO2 + ethanol solvents. Chemical Engineering Research and Design, 156. pp. 31-42. ISSN 02638762