%X The supercritical fluid extraction of Carica papaya linn. leaves in the presence of CO2 solvent and ethanol modifier was carried out with respect to four operating parameters, namely temperature (40�60 °C), pressure (18�30 MPa), solvent flow rate (3�6 mL/min) and co-solvent ratio (3 � 5 vol), for the maximization of global extract yield of Carica papaya linn. leaves. The optimized parameters obtained are as follows: temperature of 57.47 °C, pressure of 26.62 MPa, solvent flow rate of 5.43 mL/min and co-solvent ratio of 4.98 with a predicted global extract yield of 0.0806 g. Five density-based solubility models, namely Chrastil, Bian et al., Bartle et al., Sparks et al. and Méndez-Santiago and Teja models were correlated against experimental solubility data. The Méndez-Santiago and Teja model were found to be more accurate with AARD of 1.36 and R2 value of 0.873 due to the non-linearity extraction profiles of papaya leaves. © 2020
%K Carbon dioxide; Effluent treatment; Ethanol; Solubility; Supercritical fluid extraction; Supercritical fluids, Carica papaya; Experimental solubility datum; Extract yields; Operating parameters; Optimized parameter; Response surface methodology; Solubility models; Solvent flow rate, Organic solvents
%L scholars13298
%J Chemical Engineering Research and Design
%O cited By 15
%R 10.1016/j.cherd.2020.01.025
%D 2020
%I Institution of Chemical Engineers
%V 156
%A Y.H. Chai
%A S. Yusup
%A M.S.H. Ruslan
%A B.L.F. Chin
%T Supercritical fluid extraction and solubilization of Carica papaya linn. leaves in ternary system with CO2 + ethanol solvents
%P 31-42