@article{scholars13298,
           title = {Supercritical fluid extraction and solubilization of Carica papaya linn. leaves in ternary system with CO2 + ethanol solvents},
            note = {cited By 15},
          volume = {156},
             doi = {10.1016/j.cherd.2020.01.025},
       publisher = {Institution of Chemical Engineers},
         journal = {Chemical Engineering Research and Design},
           pages = {31--42},
            year = {2020},
        abstract = {The supercritical fluid extraction of Carica papaya linn. leaves in the presence of CO2 solvent and ethanol modifier was carried out with respect to four operating parameters, namely temperature (40{\^a}??60 {\^A}oC), pressure (18{\^a}??30 MPa), solvent flow rate (3{\^a}??6 mL/min) and co-solvent ratio (3 {\^a}?? 5 vol), for the maximization of global extract yield of Carica papaya linn. leaves. The optimized parameters obtained are as follows: temperature of 57.47 {\^A}oC, pressure of 26.62 MPa, solvent flow rate of 5.43 mL/min and co-solvent ratio of 4.98 with a predicted global extract yield of 0.0806 g. Five density-based solubility models, namely Chrastil, Bian et al., Bartle et al., Sparks et al. and M{\~A}{\copyright}ndez-Santiago and Teja models were correlated against experimental solubility data. The M{\~A}{\copyright}ndez-Santiago and Teja model were found to be more accurate with AARD of 1.36 and R2 value of 0.873 due to the non-linearity extraction profiles of papaya leaves. {\^A}{\copyright} 2020},
             url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078858842&doi=10.1016\%2fj.cherd.2020.01.025&partnerID=40&md5=3d572fccd04ef5ac07c2635311c3069d},
        keywords = {Carbon dioxide; Effluent treatment; Ethanol; Solubility; Supercritical fluid extraction; Supercritical fluids, Carica papaya; Experimental solubility datum; Extract yields; Operating parameters; Optimized parameter; Response surface methodology; Solubility models; Solvent flow rate, Organic solvents},
          author = {Chai, Y. H. and Yusup, S. and Ruslan, M. S. H. and Chin, B. L. F.},
            issn = {02638762}
}