TY  - JOUR
A1  - Islam, M.R.
A1  - Chowdhury, M.R.
A1  - Wakabayashi, R.
A1  - Tahara, Y.
A1  - Kamiya, N.
A1  - Moniruzzaman, M.
A1  - Goto, M.
JF  - International Journal of Pharmaceutics
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083436723&doi=10.1016%2fj.ijpharm.2020.119335&partnerID=40&md5=c02ae9fe3fed63252807ca65f30a31aa
VL  - 582
Y1  - 2020///
PB  - Elsevier B.V.
SN  - 03785173
N1  - cited By 45
N2  - Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (ILâ??EtOHâ??IPM) systems consisting of biocompatible ILs, ethanol (EtOH), and isopropyl myristate (IPM) that can dissolve a significant amount of the sparingly soluble drug acyclovir (ACV). The ternary systems were optically transparent and thermodynamically stable with a wide range of IL pertinence. An in vitro drug permeation study showed that the ILs in the ternary systems dramatically enhanced ACV permeation into and across the skin. Fourier Transform Infrared spectroscopy of the stratum corneum (sc) after treatment with ternary systems showed that the skin barrier function was reduced by disturbance of the regularly ordered arrangement of corneocytes and modification of the surface properties of the sc during permeation. Histological analysis, and skin irritation studies using a reconstructed human epidermis model showed the safety profile of the ternary system, and there were no significant changes in the structures of the sc, epidermis, and dermis. Therefore, ternary systems containing biocompatible ILs are promising for transdermal delivery of insoluble or sparingly soluble drugs. © 2020 Elsevier B.V.
TI  - Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir
ID  - scholars13142
KW  - aciclovir; alanine; alcohol; amino acid; choline; glycine; ionic liquid; myristic acid isopropyl ester; serine; aciclovir; amino acid; choline; drug carrier; ionic liquid; myristic acid derivative; solvent
KW  -  animal cell; animal experiment; Article; biocompatibility; controlled study; cytotoxicity; dermis; epidermis; female; Fourier transform infrared spectroscopy; human; human cell; in vitro study; mouse; NCTC clone 929 cell line; nonhuman; priority journal; skin function; skin irritation; skin penetration; stratum corneum; surface property; thermodynamics; Yucatan micropig; animal; Bagg albino mouse; cell line; chemistry; comparative study; cutaneous drug administration; drug formulation; metabolism; minipig; pig; skin; skin absorption; solubility
KW  -  Acyclovir; Administration
KW  -  Cutaneous; Amino Acids; Animals; Cell Line; Choline; Drug Carriers; Drug Compounding; Ethanol; Female; Humans; Ionic Liquids; Mice
KW  -  Inbred BALB C; Myristates; Skin; Skin Absorption; Solubility; Solvents; Swine; Swine
KW  -  Miniature
AV  - none
ER  -