%0 Journal Article
%@ 2190572X
%A Gopinath, S.C.B.
%A Perumal, V.
%A Xuan, S.
%D 2020
%F scholars:13108
%I Springer
%J 3 Biotech
%K ethanolamine; microRNA 155; streptavidin, Article; breast cancer; cancer diagnosis; cancer growth; chemical interaction; female; gene expression; gene identification; gene targeting; genetic complementation; human; limit of detection; priority journal; RNA sequence
%N 6
%R 10.1007/s13205-020-02261-x
%T MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer
%U https://khub.utp.edu.my/scholars/13108/
%V 10
%X This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer. © 2020, King Abdulaziz City for Science and Technology.
%Z cited By 4