eprintid: 12938
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/29/38
datestamp: 2023-11-10 03:27:30
lastmod: 2023-11-10 03:27:30
status_changed: 2023-11-10 01:49:55
type: article
metadata_visibility: show
creators_name: Chaudhry, G.-E.-S.
creators_name: Akim, A.
creators_name: Zafar, M.
creators_name: Abdullah, M.
creators_name: Sung, Y.
creators_name: Muhammad, T.
title: Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
ispublished: pub
keywords: adenosine diphosphate; adenosine triphosphate; hyaluronic acid; nanoparticle; paclitaxel; protein kinase B; protein p53; RhoA guanine nucleotide binding protein, apoptosis; Article; breast cancer cell line; cancer cell; cell migration; cell survival; colorectal cancer cell line; concentration response; controlled study; flow cytometry; human; human cell; metastasis; priority journal
note: cited By 7
abstract: Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis. © 2020 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer - Medknow.
date: 2020
publisher: Wolters Kluwer Medknow Publications
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089304908&doi=10.4103%2fjaptr.JAPTR_26_20&partnerID=40&md5=10ace7e6abc8274eed54aae901a62d56
id_number: 10.4103/japtr.JAPTR₂₆₂₀
full_text_status: none
publication: Journal of Advanced Pharmaceutical Technology and Research
volume: 11
number: 3
pagerange: 101-106
refereed: TRUE
issn: 22314040
citation:   Chaudhry, G.-E.-S. and Akim, A. and Zafar, M. and Abdullah, M. and Sung, Y. and Muhammad, T.  (2020) Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA.  Journal of Advanced Pharmaceutical Technology and Research, 11 (3).  pp. 101-106.  ISSN 22314040