TY  - JOUR
N1  - cited By 7
SP  - 101
A1  - Chaudhry, G.-E.-S.
A1  - Akim, A.
A1  - Zafar, M.
A1  - Abdullah, M.
A1  - Sung, Y.
A1  - Muhammad, T.
EP  - 106
IS  - 3
VL  - 11
TI  - Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
PB  - Wolters Kluwer Medknow Publications
ID  - scholars12938
SN  - 22314040
Y1  - 2020///
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089304908&doi=10.4103%2fjaptr.JAPTR_26_20&partnerID=40&md5=10ace7e6abc8274eed54aae901a62d56
AV  - none
KW  - adenosine diphosphate; adenosine triphosphate; hyaluronic acid; nanoparticle; paclitaxel; protein kinase B; protein p53; RhoA guanine nucleotide binding protein
KW  -  apoptosis; Article; breast cancer cell line; cancer cell; cell migration; cell survival; colorectal cancer cell line; concentration response; controlled study; flow cytometry; human; human cell; metastasis; priority journal
JF  - Journal of Advanced Pharmaceutical Technology and Research
N2  - Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis. © 2020 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer - Medknow.
ER  -