<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA"^^ . "Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis. © 2020 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer - Medknow."^^ . "2020" . . "11" . "3" . . "Wolters Kluwer Medknow Publications"^^ . . . "Journal of Advanced Pharmaceutical Technology and Research"^^ . . . "22314040" . . . . . . . . . . . . . . . . . . . . . . "G.-E.-S."^^ . "Chaudhry"^^ . "G.-E.-S. Chaudhry"^^ . . "M."^^ . "Zafar"^^ . "M. Zafar"^^ . . "Y."^^ . "Sung"^^ . "Y. Sung"^^ . . "A."^^ . "Akim"^^ . "A. Akim"^^ . . "M."^^ . "Abdullah"^^ . "M. Abdullah"^^ . . "T."^^ . "Muhammad"^^ . "T. Muhammad"^^ . . . . . "HTML Summary of #12938 \n\nInduction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA\n\n" . "text/html" . .