TY  - JOUR
AV  - none
N1  - cited By 11
SP  - 1691
TI  - Automated Thresholding Method for fNIRS-Based Functional Connectivity Analysis: Validation with a Case Study on Alzheimer's Disease
PB  - Institute of Electrical and Electronics Engineers Inc.
SN  - 15344320
EP  - 1701
IS  - 8
N2  - While functional integration has been suggested to reflect brain health, non-standardized network thresholding methods complicate network interpretation. We propose a new method to analyze functional near-infrared spectroscopy-based functional connectivity (fNIRS-FC). In this study, we employed wavelet analysis for motion correction and orthogonal minimal spanning trees (OMSTs) to derive the brain connectivity. The proposed method was applied to an Alzheimer's disease (AD) dataset and was compared with a number of well-known thresholding techniques. The results demonstrated that the proposed method outperformed the benchmarks in filtering cost-effective networks and in differentiation between patients with mild AD and healthy controls. The results also supported the proposed method as a feasible technique to analyze fNIRS-FC, especially with cost-efficiency, assortativity and laterality as a set of effective features for the diagnosis of AD. © 2001-2011 IEEE.
ID  - scholars12854
KW  - Cost effectiveness; Diagnosis; Infrared devices; Near infrared spectroscopy
KW  -  Automated thresholding; Cost-effective network; Functional connectivity; Functional integration; Functional near infrared spectroscopy; Minimal spanning tree; Thresholding methods; Thresholding techniques
KW  -  Neurodegenerative diseases
KW  -  aged; algorithm; Alzheimer disease; Article; assortativity; case study; clinical article; Clinical Dementia Rating; controlled study; cost effectiveness analysis; female; functional connectivity; functional near-infrared spectroscopy; human; male; mathematical model; mathematical parameters; Mini Mental State Examination; prefrontal cortex; validation process; brain; brain mapping; near infrared spectroscopy; nuclear magnetic resonance imaging; wavelet analysis
KW  -  Alzheimer Disease; Brain; Brain Mapping; Humans; Magnetic Resonance Imaging; Spectroscopy
KW  -  Near-Infrared; Wavelet Analysis
Y1  - 2020///
A1  - Chan, Y.L.
A1  - Ung, W.C.
A1  - Lim, L.G.
A1  - Lu, C.-K.
A1  - Kiguchi, M.
A1  - Tang, T.B.
JF  - IEEE Transactions on Neural Systems and Rehabilitation Engineering
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089204163&doi=10.1109%2fTNSRE.2020.3007589&partnerID=40&md5=5994e65315a872bd0e6c465dd46107df
VL  - 28
ER  -