eprintid: 12773
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/27/73
datestamp: 2023-11-10 03:27:20
lastmod: 2023-11-10 03:27:20
status_changed: 2023-11-10 01:49:29
type: article
metadata_visibility: show
creators_name: Sakuragi, M.
creators_name: Yano, R.
creators_name: Hasnol, S.B.M.
creators_name: Kusakabe, K.
title: Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
ispublished: pub
keywords: Eutectics; Microemulsions; Resveratrol; Surface active agents, Deep eutectic solvents; High solubility; Skin penetration; Spherical micelles; Stratum corneum; Structural characterization; Surfactant composition; Transdermal permeation, Micelles
note: cited By 7
abstract: Inclusion of a large amount of deep eutectic solvent (DES) in a microemulsion (ME) may enhance transdermal permeation of resveratrol (RSV) due to its high solubility in DES of the inner phase. We prepared MEs with different DES loading and surfactant composition, and investigated the entrapment amount of RSV, the structures of the MEs, and their skin penetration amount. We found that MEs at Tween-80/Span-20 = 4/1 (wt/wt) (T4S1) were able to contain the largest amount of DES in the inner phase. The structural characterization results showed that T4S1-MEs containing more than 20 wt DES and less than 10 wt DES formed a vesicle containing DES in the membrane of surfactants and a spherical micelle containing DES in the inner phase, respectively. The vesicles containing more than 20 wt DES were able to trap a larger amount of RSV and deliver more RSV through the stratum corneum compared to the spherical micelles containing less than 10 wt DES. © 2020 The Japan Society of Applied Physics.
date: 2020
publisher: IOP Publishing Ltd
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091657124&doi=10.35848%2f1347-4065%2fabaa94&partnerID=40&md5=0c91b04d200aa74cd8469e2bfbecd12f
id_number: 10.35848/1347-4065/abaa94
full_text_status: none
publication: Japanese Journal of Applied Physics
volume: 59
number: 9
refereed: TRUE
issn: 00214922
citation:   Sakuragi, M. and Yano, R. and Hasnol, S.B.M. and Kusakabe, K.  (2020) Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol.  Japanese Journal of Applied Physics, 59 (9).   ISSN 00214922