TY  - JOUR
N1  - cited By 11
KW  - Biomolecules; Cell culture; Molecular modeling; Precipitation (chemical)
KW  -  Anti-proliferative activities; Continuous variation methods; Coprecipitation method; Inclusion behavior; Inclusion complex; Solid inclusion complexes; Stoichiometric ratio; Supramolecular complexes
KW  -  Cyclodextrins
KW  -  beta cyclodextrin; guanosine; antineoplastic agent; beta cyclodextrin derivative; guanosine
KW  -  absorption; antiproliferative activity; apoptosis; Article; association constant; cell proliferation; cell viability; controlled study; differential scanning calorimetry; drug toxicity; evaluation study; field emission scanning electron microscopy; fluorescence; Fourier transform infrared spectroscopy; Hep-G2 cell line; human; human cell; IC50; molecular docking; nuclear magnetic resonance; precipitation; priority journal; supramolecular chemistry; thermogravimetry; X ray diffraction; chemistry; conformation; drug effect
KW  -  Antineoplastic Agents; beta-Cyclodextrins; Cell Proliferation; Guanosine; Hep G2 Cells; Humans; Molecular Conformation; Molecular Docking Simulation
A1  - Prabu, S.
A1  - Samad, N.A.
A1  - Ahmad, N.A.
A1  - Jumbri, K.
A1  - Raoov, M.
A1  - Rahim, N.Y.
A1  - Samikannu, K.
A1  - Mohamad, S.
Y1  - 2020///
SN  - 00086215
TI  - Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity
ID  - scholars12580
AV  - none
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090364556&doi=10.1016%2fj.carres.2020.108138&partnerID=40&md5=fd9cf4353a742d22bed70886f9c4742d
VL  - 497
JF  - Carbohydrate Research
PB  - Elsevier Ltd
N2  - The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in the liquid, solid and virtual state were investigated. The absorption and fluorescence spectral were used to determine the inclusion behavior in liquid state. FT-IR, NMR, TGA, DSC, PXRD and FESEM techniques were used to investigate the inclusion behavior in solid-state, meanwhile the virtual state studies are done by molecular docking. The solid inclusion complex (GU: β-CD) was prepared by using the co-precipitation method. The binding constant (K) of (GU: β-CD) was calculated by using Benesi-Hildebrand. Besides that, the 1:1 stoichiometric ratio of inclusion complex was confirmed by using the Benesi-Hildebrand plot and Job's plot of continuous variation method. The most preferable model of GU: β-CD that suggested via molecular docking studies was in good agreement with experimental results. The inclusion complex of GU: β-CD exerted its toxicity effects towards HepG2 cell lines based on the reduced number of cell viability and lowest IC50 value compared to the GU and β-CD viability. © 2020 Elsevier Ltd
ER  -