relation: https://khub.utp.edu.my/scholars/12580/
title: Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity
creator: Prabu, S.
creator: Samad, N.A.
creator: Ahmad, N.A.
creator: Jumbri, K.
creator: Raoov, M.
creator: Rahim, N.Y.
creator: Samikannu, K.
creator: Mohamad, S.
description: The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in the liquid, solid and virtual state were investigated. The absorption and fluorescence spectral were used to determine the inclusion behavior in liquid state. FT-IR, NMR, TGA, DSC, PXRD and FESEM techniques were used to investigate the inclusion behavior in solid-state, meanwhile the virtual state studies are done by molecular docking. The solid inclusion complex (GU: β-CD) was prepared by using the co-precipitation method. The binding constant (K) of (GU: β-CD) was calculated by using Benesi-Hildebrand. Besides that, the 1:1 stoichiometric ratio of inclusion complex was confirmed by using the Benesi-Hildebrand plot and Job's plot of continuous variation method. The most preferable model of GU: β-CD that suggested via molecular docking studies was in good agreement with experimental results. The inclusion complex of GU: β-CD exerted its toxicity effects towards HepG2 cell lines based on the reduced number of cell viability and lowest IC50 value compared to the GU and β-CD viability. © 2020 Elsevier Ltd
publisher: Elsevier Ltd
date: 2020
type: Article
type: PeerReviewed
identifier:   Prabu, S. and Samad, N.A. and Ahmad, N.A. and Jumbri, K. and Raoov, M. and Rahim, N.Y. and Samikannu, K. and Mohamad, S.  (2020) Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity.  Carbohydrate Research, 497.   ISSN 00086215     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090364556&doi=10.1016%2fj.carres.2020.108138&partnerID=40&md5=fd9cf4353a742d22bed70886f9c4742d
relation: 10.1016/j.carres.2020.108138
identifier: 10.1016/j.carres.2020.108138