%X We report a new series of lipid-based biocompatible ionic liquids (LBILs) consisting of the long-chain phosphonium compound 1,2-dimyristoyl-sn-glycero-3-ethyl-phosphatidylcholine as the cation and the long-chain fatty acids stearic acid, oleic acid, or linoleic acid as anions. These materials were found to be completely miscible with many polar and nonpolar organic solvents as well as dispersible in water. These LBILs also exhibited excellent biocompatibility with an artificial three-dimensional human epidermis model. © 2020 The Royal Society of Chemistry. %K Ionic liquids; Linoleic acid; Monounsaturated fatty acids, Human epidermis; Long chain fatty acid; Long chains; Nonpolar organic solvents, Biocompatibility, biomaterial; ionic liquid; lipid; solvent, chemical structure; chemistry; epidermis; human; synthesis, Biocompatible Materials; Epidermis; Humans; Ionic Liquids; Lipids; Molecular Structure; Solvents %L scholars12480 %J Chemical Communications %O cited By 20 %R 10.1039/d0cc04491a %N 89 %D 2020 %I Royal Society of Chemistry %A S. Uddin %A M.R. Chowdhury %A R. Wakabayashi %A N. Kamiya %A M. Moniruzzaman %A M. Goto %V 56 %T Lipid based biocompatible ionic liquids: Synthesis, characterization and biocompatibility evaluation %P 13756-13759