eprintid: 12416
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/24/16
datestamp: 2023-11-10 03:26:58
lastmod: 2023-11-10 03:26:58
status_changed: 2023-11-10 01:48:43
type: article
metadata_visibility: show
creators_name: Ismail, A.
creators_name: Chen, H.C.
creators_name: Faye, I.
creators_name: Tang, T.B.
title: Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
ispublished: pub
keywords: animal; blood flow; carotid artery obstruction; disease model; eye; hemodynamics; laser Doppler flowmetry; Leporidae; male; pathophysiology; physiology; pulse wave; vascularization, Animals; Carotid Stenosis; Disease Models, Animal; Eye; Hemodynamics; Laser-Doppler Flowmetry; Male; Pulse Wave Analysis; Rabbits; Regional Blood Flow
note: cited By 1
abstract: Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75 stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye. © 2020, The Author(s).
date: 2020
publisher: Nature Research
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091643584&doi=10.1038%2fs41598-020-72556-9&partnerID=40&md5=67b8d8c6ca558b60dfbcda945f6995fa
id_number: 10.1038/s41598-020-72556-9
full_text_status: none
publication: Scientific Reports
volume: 10
number: 1
refereed: TRUE
issn: 20452322
citation:   Ismail, A. and Chen, H.C. and Faye, I. and Tang, T.B.  (2020) Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model.  Scientific Reports, 10 (1).   ISSN 20452322