eprintid: 12230
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/22/30
datestamp: 2023-11-10 03:26:46
lastmod: 2023-11-10 03:26:46
status_changed: 2023-11-10 01:17:11
type: article
metadata_visibility: show
creators_name: Sutoko, S.
creators_name: Chan, Y.L.
creators_name: Obata, A.
creators_name: Sato, H.
creators_name: Maki, A.
creators_name: Numata, T.
creators_name: Funane, T.
creators_name: Atsumori, H.
creators_name: Kiguchi, M.
creators_name: Tang, T.B.
creators_name: Li, Y.
creators_name: Frederick, B.D.
creators_name: Tong, Y.
title: Denoising of neuronal signal from mixed systemic low-frequency oscillation using peripheral measurement as noise regressor in near-infrared imaging
ispublished: pub
keywords: Brain; Chemical activation; Image segmentation; Infrared devices; Near infrared spectroscopy; Thermography (imaging), De-noising; Low frequency oscillations; peripheral; systemic noise; Working memory, Signal denoising, article; controlled study; ear; evoked response; false positive result; finger; functional near-infrared spectroscopy; noise; oscillation; prefrontal cortex; rest; working memory
note: cited By 13
abstract: Functional near-infrared spectroscopy (fNIRS) is a noninvasive functional imaging technique measuring hemodynamic changes including oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin. Low frequency (LF; 0.01 to 0.15 Hz) band is commonly analyzed in fNIRS to represent neuronal activation. However, systemic physiological artifacts (i.e., nonneuronal) likely occur also in overlapping frequency bands. We measured peripheral photoplethysmogram (PPG) signal concurrently with fNIRS (at prefrontal region) to extract the low-frequency oscillations (LFOs) as systemic noise regressors. We investigated three main points in this study: (1) the relationship between prefrontal fNIRS and peripheral PPG signals; (2) the denoising potential using these peripheral LFOs, and (3) the innovative ways to avoid the false-positive result in fNIRS studies. We employed spatial working memory (WM) and control tasks (e.g., resting state) to illustrate these points. Our results showed: (1) correlation between signals from prefrontal fNIRS and peripheral PPG is region-dependent. The high correlation with peripheral ear signal (i.e., O2Hb) occurred mainly in frontopolar regions in both spatial WM and control tasks. This may indicate the finding of task-dependent effect even in peripheral signals. We also found that the PPG recording at the ear has a high correlation with prefrontal fNIRS signal than the finger signals. (2) The systemic noise was reduced by 25 to 34 on average across regions, with a maximum of 39 to 58 in the highly correlated frontopolar region, by using these peripheral LFOs as noise regressors. (3) By performing the control tasks, we confirmed that the statistically significant activation was observed in the spatial WM task, not in the controls. This suggested that systemic (and any other) noises unlikely violated the major statistical inference. (4) Lastly, by denoising using the task-related signals, the significant activation of region-of-interest was still observed suggesting the manifest task-evoked response in the spatial WM task. © The Authors.
date: 2019
publisher: SPIE
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062706083&doi=10.1117%2f1.NPh.6.1.015001&partnerID=40&md5=23029ceec4fbea4faee55c9a3729fe58
id_number: 10.1117/1.NPh.6.1.015001
full_text_status: none
publication: Neurophotonics
volume: 6
number: 1
refereed: TRUE
issn: 2329423X
citation:   Sutoko, S. and Chan, Y.L. and Obata, A. and Sato, H. and Maki, A. and Numata, T. and Funane, T. and Atsumori, H. and Kiguchi, M. and Tang, T.B. and Li, Y. and Frederick, B.D. and Tong, Y.  (2019) Denoising of neuronal signal from mixed systemic low-frequency oscillation using peripheral measurement as noise regressor in near-infrared imaging.  Neurophotonics, 6 (1).   ISSN 2329423X