eprintid: 12021
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/20/21
datestamp: 2023-11-10 03:26:34
lastmod: 2023-11-10 03:26:34
status_changed: 2023-11-10 01:16:42
type: article
metadata_visibility: show
creators_name: Pan, H.
creators_name: Lakshmipriya, T.
creators_name: Gopinath, S.C.B.
creators_name: Anbu, P.
title: High-affinity detection of metal-mediated nephrotoxicity by aptamer nanomaterial complementation
ispublished: pub
keywords: Chemical detection; Chromates; Damage detection; Detoxification; Lead compounds; Metal ions; Metalloids; Nanostructured materials, Aptamers; Complementation; Conjugated systems; Detection system; Developing strategy; Kidney; Metallic nanoparticles; Nephrotoxicity, Metals, aptamer; arsenic; binding protein; cadmium; lead; mercury; metal; metal ion; nanomaterial, adsorption; bioaccumulation; colorimetry; heavy metal poisoning; human; kidney tubule absorption; limit of detection; nephrotoxicity; priority journal; Review
note: cited By 2
abstract: Nephrotoxicity, a chronic renal disease that results from the accumulation of endogenous and exogenous toxins in the kidney, disturbs the excretion and detoxification function of the kidney. Metal-mediated nephrotoxicity is induced by toxic metals/metalloids such as mercury, lead, arsenic, chromate, uranium, and cadmium. These materials become concentrated in the kidneys and injure the nephrons. Developing strategies to detect these metal ions will enable the earlier identification of kidney damage. An aptamer, an artificial antibody generated against a wide range of targets including metal ions, may be the right tool for the detection of metal ions associated with renal injury. The use of a detection system consisting of an aptamer and metallic nanoparticles is a potential way to overcome nephrotoxicity. Here, we discuss the detection of metal-mediated nephrotoxicity caused by metals/metalloids using the aptamer and nanomaterial-conjugated system. © 2019 Bentham Science Publishers.
date: 2019
publisher: Bentham Science Publishers
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073774604&doi=10.2174%2f1573413715666190115155917&partnerID=40&md5=c79abe954155b8da32aa09d746abb4f3
id_number: 10.2174/1573413715666190115155917
full_text_status: none
publication: Current Nanoscience
volume: 15
number: 6
pagerange: 549-556
refereed: TRUE
issn: 15734137
citation:   Pan, H. and Lakshmipriya, T. and Gopinath, S.C.B. and Anbu, P.  (2019) High-affinity detection of metal-mediated nephrotoxicity by aptamer nanomaterial complementation.  Current Nanoscience, 15 (6).  pp. 549-556.  ISSN 15734137