TY  - JOUR
N2  - A new sample preparation method is proposed for the extraction of pharmaceutical compounds (Metformin, Phenyl biguanide, and Phenformin) of varied hydrophilicity, dissolved in an aqueous sample. When in contact with an organic phase, an interfacial potential is imposed by the presence of an ion, tetramethylammonium (TMA+), common to each phase. The interfacial potential difference drives the transfer of ionic analytes across the interface and allows it to reach up to nearly 100 extraction efficiency and a 60-fold enrichment factor in optimized extraction conditions as determined by HPLC analysis. © 2019 American Chemical Society.
IS  - 11
ID  - scholars11537
KW  - High performance liquid chromatography
KW  -  Enrichment factors; Extraction conditions; Extraction efficiencies; Interfacial potential; Liquid-liquid extraction; Pharmaceutical compounds; Sample preparation methods; Tetramethylammonium
KW  -  Extraction
JF  - Analytical Chemistry
A1  - Jajuli, M.N.
A1  - Hussin, M.H.
A1  - Saad, B.
A1  - Rahim, A.A.
A1  - Hébrant, M.
A1  - Herzog, G.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066853156&doi=10.1021%2facs.analchem.9b01674&partnerID=40&md5=d98d811bb10c0749683ae7ac34ffa277
VL  - 91
Y1  - 2019///
N1  - cited By 11
SP  - 7466
TI  - Electrochemically Modulated Liquid-Liquid Extraction for Sample Enrichment
AV  - none
EP  - 7473
PB  - American Chemical Society
SN  - 00032700
ER  -