@article{scholars11537, title = {Electrochemically Modulated Liquid-Liquid Extraction for Sample Enrichment}, doi = {10.1021/acs.analchem.9b01674}, note = {cited By 11}, volume = {91}, number = {11}, pages = {7466--7473}, publisher = {American Chemical Society}, journal = {Analytical Chemistry}, year = {2019}, author = {Jajuli, M. N. and Hussin, M. H. and Saad, B. and Rahim, A. A. and H{\~A}{\copyright}brant, M. and Herzog, G.}, issn = {00032700}, abstract = {A new sample preparation method is proposed for the extraction of pharmaceutical compounds (Metformin, Phenyl biguanide, and Phenformin) of varied hydrophilicity, dissolved in an aqueous sample. When in contact with an organic phase, an interfacial potential is imposed by the presence of an ion, tetramethylammonium (TMA+), common to each phase. The interfacial potential difference drives the transfer of ionic analytes across the interface and allows it to reach up to nearly 100 extraction efficiency and a 60-fold enrichment factor in optimized extraction conditions as determined by HPLC analysis. {\^A}{\copyright} 2019 American Chemical Society.}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066853156&doi=10.1021\%2facs.analchem.9b01674&partnerID=40&md5=d98d811bb10c0749683ae7ac34ffa277}, keywords = {High performance liquid chromatography, Enrichment factors; Extraction conditions; Extraction efficiencies; Interfacial potential; Liquid-liquid extraction; Pharmaceutical compounds; Sample preparation methods; Tetramethylammonium, Extraction} }