<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations"^^ . "In order to prevent common hypersensitivity reactions to paclitaxel injections (Taxol), we previously reported an ionic liquid-mediated paclitaxel (IL-PTX)formulation with small particle size and narrow size distribution. The preliminary work showed high PTX solubility in the IL, and the formulation demonstrated similar antitumor activity to Taxol, while inducing a smaller hypersensitivity effect in in vitro cell experiments. In this study, the stability of the IL-PTX formulation was monitored by quantitative HPLC analysis, which showed that IL-PTX was more stable at 4 °C than at room temperature. The in vivo study showed that the IL-PTX formulation could be used in a therapeutic application as a biocompatible component of a drug delivery system. To assess the in-vivo biocompatibility, IL or IL-mediated formulations were administered intravenously by maintaining physiological buffered conditions (neutral pH and isotonic salt concentration). From in vivo pharmacokinetics data, the IL-PTX formulation was found to have a similar systemic circulation time and slower elimination rate compared to cremophor EL mediated paclitaxel (CrEL-PTX). Furthermore, in vivo antitumor and hypersensitivity experiments in C57BL/6 mice revealed that IL-PTX had similar antitumor activity to CrEL-PTX, but a significantly smaller hypersensitivity effect compared with CrEL-PTX. Therefore, the IL-mediated formulation has potential to be an effective and safe drug delivery system for PTX. © 2019 Elsevier B.V."^^ . "2019" . . "565" . . "Elsevier B.V."^^ . . . "International Journal of Pharmaceutics"^^ . . . "03785173" . . . . . . . . . . . . . . . . . . . . . . . . . "R."^^ . "Wakabayashi"^^ . "R. Wakabayashi"^^ . . "M."^^ . "Goto"^^ . "M. Goto"^^ . . "Y."^^ . "Tahara"^^ . "Y. Tahara"^^ . . "M.R."^^ . "Chowdhury"^^ . "M.R. Chowdhury"^^ . . "N."^^ . "Kamiya"^^ . "N. Kamiya"^^ . . "R.M."^^ . "Moshikur"^^ . "R.M. Moshikur"^^ . . "M."^^ . "Moniruzzaman"^^ . "M. Moniruzzaman"^^ . . . . . "HTML Summary of #11523 \n\nIn vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations\n\n" . "text/html" . .