eprintid: 10944
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/09/44
datestamp: 2023-11-09 16:37:33
lastmod: 2023-11-09 16:37:33
status_changed: 2023-11-09 16:32:34
type: article
metadata_visibility: show
creators_name: Moniruzzaman, M.
creators_name: Mahmood, H.
creators_name: Goto, M.
title: Ionic Liquid Based Nanocarriers for Topical and Transdermal Drug Delivery
ispublished: pub
keywords: Drug products; Ionic drugs; Light scattering; Liquids; Microemulsions; Nonionic surfactants; Polyethylene oxides; Viruses, Cytotoxicity assays; Drug administration; Nano-delivery systems; Pharmaceutical industry; Size and size distributions; Sorbitan monooleate; Transdermal administration; Transdermal drug delivery, Ionic liquids
note: cited By 1
abstract: In the pharmaceutical industry, there are challenges in topical and transdermal administration of drugs, which are sparingly soluble in water and most organic solvents. Ionic liquids (ILs) have been found to be very effective for dissolution of sparingly soluble drugs. However, hydrophilic IL-borne drugs cannot penetrate into or across the skin because of the highly hydrophobic barrier function of the outer skin. In this chapter we report a novel IL-in-oil (IL/o) microemulsion (ME) that is able to dissolve a significant amount of sparingly soluble drug, acyclovir, in the IL core while the continuous oil phase can provide the desired features for topical/transdermal transport through the skin. The ME is composed of a blend of the nonionic surfactants polyoxyethylene sorbitan monooleate (Tween 80) and sorbitan laurate (Span 20), isopropyl myristate (IPM) as an oil phase, and the IL C1mim(MeO)2PO2 (dimethylimidazolium dimethylphosphate) as a dispersed phase. The size and size distribution of the aggregates in the MEs were characterized by dynamic light scattering, showing formation of the nanocarrier in the size range 8-34 nm. In vitro drug permeation studies into and across the skin showed that the IL/o ME increased drug administration compared with other formulations. The safety profile of the new carrier was evaluated using a cytotoxicity assay on the human epidermal model LabCyte. We believe that these IL-assisted nonaqueous MEs can serve as a versatile and efficient nanodelivery system for sparingly soluble drug molecules. © The Royal Society of Chemistry 2018.
date: 2018
publisher: Royal Society of Chemistry
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030782545&doi=10.1039%2f9781788011839-00390&partnerID=40&md5=5546af557a952db437f2a6f05f61e7ac
id_number: 10.1039/9781788011839-00390
full_text_status: none
publication: RSC Smart Materials
volume: 2018-J
number: 28
pagerange: 390-403
refereed: TRUE
issn: 20460066
citation:   Moniruzzaman, M. and Mahmood, H. and Goto, M.  (2018) Ionic Liquid Based Nanocarriers for Topical and Transdermal Drug Delivery.  RSC Smart Materials, 2018-J (28).  pp. 390-403.  ISSN 20460066