relation: https://khub.utp.edu.my/scholars/10380/
title: Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
creator: Tan, W.-N.
creator: Lim, J.-Q.
creator: Afiqah, F.
creator: Nik Mohamed Kamal, N.N.S.
creator: Abdul Aziz, F.A.
creator: Tong, W.-Y.
creator: Leong, C.-R.
creator: Lim, J.-W.
description: Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9) and palmitic acid (21.9), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5) and β-caryophyllene (16.9). Treatment of MCF-7 cells using EO-L (100 μg/mL) caused more than 50 cell death while EO-SB did not induce cytotoxic effect. EO-L has stimulated the growth of BEAS-2B normal cells, but not in MCF-7 cancerous cells. The IC50 of EO-L in MCF-7 and BEAS-2B cells were 71 and 95 μg/mL, respectively. A combination treatment of EO-L and tamoxifen induced more cell death than the treatment with drug alone at lower doses. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
publisher: Taylor and Francis Ltd.
date: 2018
type: Article
type: PeerReviewed
identifier:   Tan, W.-N. and Lim, J.-Q. and Afiqah, F. and Nik Mohamed Kamal, N.N.S. and Abdul Aziz, F.A. and Tong, W.-Y. and Leong, C.-R. and Lim, J.-W.  (2018) Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen.  Natural Product Research, 32 (7).  pp. 854-858.  ISSN 14786419     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026899454&doi=10.1080%2f14786419.2017.1361951&partnerID=40&md5=cdb2baa43b08f42921afc5ac36241547
relation: 10.1080/14786419.2017.1361951
identifier: 10.1080/14786419.2017.1361951