eprintid: 10300
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/03/00
datestamp: 2023-11-09 16:36:55
lastmod: 2023-11-09 16:36:55
status_changed: 2023-11-09 16:31:04
type: article
metadata_visibility: show
creators_name: Elaina, N.S.
creators_name: Malik, A.S.
creators_name: Shams, W.K.
creators_name: Badruddin, N.
creators_name: Abdullah, J.M.
creators_name: Reza, M.F.
title: Localized N20 Component of Somatosensory Evoked Magnetic Fields in Frontoparietal Brain Tumor Patients Using Noise-Normalized Approaches
ispublished: pub
keywords: accuracy; adult; Article; astrocytoma; brain mapping; brain region; brain tumor; Brodmann area 3n; clinical article; controlled study; dipole; electrostimulation; female; frontoparietal cortex; glioblastoma; human; left hemisphere; low resolution brain electromagnetic tomography; magnetic field; magnetoencephalography; male; median nerve; meningioma; middle aged; nuclear magnetic resonance imaging; quantitative analysis; reliability; right hemisphere; sensorimotor cortex; sensorimotor function; somatosensory cortex; somatosensory evoked potential; young adult; brain tumor; diagnostic imaging; magnetic field; magnetoencephalography, Adult; Brain Mapping; Brain Neoplasms; Evoked Potentials, Somatosensory; Female; Humans; Magnetic Fields; Magnetoencephalography; Male; Middle Aged; Somatosensory Cortex; Young Adult
note: cited By 2
abstract: Purpose: To localize sensorimotor cortical activation in 10 patients with frontoparietal tumors using quantitative magnetoencephalography (MEG) with noise-normalized approaches. Material and Methods: Somatosensory evoked magnetic fields (SEFs) were elicited in 10 patients with somatosensory tumors and in 10 control participants using electrical stimulation of the median nerve via the right and left wrists. We localized the N20m component of the SEFs using dynamic statistical parametric mapping (dSPM) and standardized low-resolution brain electromagnetic tomography (sLORETA) combined with 3D magnetic resonance imaging (MRI). The obtained coordinates were compared between groups. Finally, we statistically evaluated the N20m parameters across hemispheres using non-parametric statistical tests. Results: The N20m sources were accurately localized to Brodmann area 3b in all members of the control group and in seven of the patients; however, the sources were shifted in three patients relative to locations outside the primary somatosensory cortex (SI). Compared with the affected (tumor) hemispheres in the patient group, N20m amplitudes and the strengths of the current sources were significantly lower in the unaffected hemispheres and in both hemispheres of the control group. These results were consistent for both dSPM and sLORETA approaches. Conclusion: Tumors in the sensorimotor cortex lead to cortical functional reorganization and an increase in N20m amplitude and current-source strengths. Noise-normalized approaches for MEG analysis that are integrated with MRI show accurate and reliable localization of sensorimotor function. © 2017, Springer-Verlag Berlin Heidelberg.
date: 2018
publisher: Urban und Vogel GmbH
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010711604&doi=10.1007%2fs00062-017-0557-0&partnerID=40&md5=57a3417d5819dedd6caff2043526d58c
id_number: 10.1007/s00062-017-0557-0
full_text_status: none
publication: Clinical Neuroradiology
volume: 28
number: 2
pagerange: 267-281
refereed: TRUE
issn: 18691439
citation:   Elaina, N.S. and Malik, A.S. and Shams, W.K. and Badruddin, N. and Abdullah, J.M. and Reza, M.F.  (2018) Localized N20 Component of Somatosensory Evoked Magnetic Fields in Frontoparietal Brain Tumor Patients Using Noise-Normalized Approaches.  Clinical Neuroradiology, 28 (2).  pp. 267-281.  ISSN 18691439