%0 Journal Article
%@ 09205063
%A Iqbal, B.
%A Sarfaraz, Z.
%A Muhammad, N.
%A Ahmad, P.
%A Iqbal, J.
%A Khan, Z.U.H.
%A Gonfa, G.
%A Iqbal, F.
%A Jamal, A.
%A Rahim, A.
%D 2018
%F scholars:10136
%I Taylor and Francis Inc.
%J Journal of Biomaterials Science, Polymer Edition
%K Biocompatibility; Bone; Calcium chloride; Cell proliferation; Collagen; Hydroxyapatite; Ionic liquids; Mechanical properties; Sodium alginate, Alginate solutions; Anti-bacterial activity; beads; Biological properties; Bone-fillers; Chloride solutions; Different proportions; Microhardness testing, Fillers, alginic acid; biomaterial; calcium chloride; chloramphenicol; collagen; distilled water; gentamicin; hydroxyapatite; ionic liquid; nanobead; solvent; alginic acid; antiinfective agent; collagen; hydroxyapatite; ionic liquid; microsphere; solvent; water, adsorption; animal cell; antibacterial activity; Article; biocompatibility; biomechanics; body fluid; bone defect; bone regeneration; cell proliferation; cell viability; controlled study; disk diffusion; dissolution; hardness; hemolysis assay; hydrogen bond; in vitro study; infrared spectroscopy; mesenchymal stem cell; MTT assay; nonhuman; priority journal; rat; scanning electron microscopy; Streptococcus mutans; synthesis; thermogravimetry; ultraviolet spectrophotometry; water transport; X ray powder diffraction; zone of inhibition; animal; bone; cell survival; chemistry; cytology; drug effect; human, Adsorption; Alginates; Animals; Anti-Bacterial Agents; Biocompatible Materials; Biomechanical Phenomena; Bone and Bones; Bone Regeneration; Calcium Chloride; Cell Proliferation; Cell Survival; Collagen; Durapatite; Humans; Ionic Liquids; Mesenchymal Stem Cells; Microspheres; Rats; Solvents; Water
%N 10
%P 1168-1184
%R 10.1080/09205063.2018.1443604
%T Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
%U https://khub.utp.edu.my/scholars/10136/
%V 29
%X In this study, collagen/alginate/hydroxyapatite beads having different proportions were prepared as bone fillers for the restoration of osteological defects. Ionic liquid was used to dissolve the collagen and subsequently the solution was mixed with sodium alginate solution. Hydroxyapatite was added in different proportions, with the rationale to enhance mechanical as well as biological properties. The prepared solutions were given characteristic bead shapes by dropwise addition into calcium chloride solution. The prepared beads were characterized using FTIR, XRD, TGA and SEM analysis. Microhardness testing was used to evaluate the mechanical properties. The prepared beads were investigated for water adsorption behavior to ascertain its ability for body fluid uptake and adjusted accordingly to the bone cavity. Drug loading and subsequently the antibacterial activity was investigated for the prepared beads. The biocompatibility was assessed using the hemolysis testing and cell proliferation assay. The prepared collagen-alginate-HA beads, having biocompatibility and good mechanical properties, have showed an option of promising biologically active bone fillers for bone regeneration. © 2018 Informa UK Limited, trading as Taylor & Francis Group.
%Z cited By 24