TY  - JOUR
TI  - Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
SP  - 1711
N1  - cited By 4
AV  - none
EP  - 1721
SN  - 0721832X
PB  - Springer Verlag
KW  - caffeine; guarana extract; caffeine; central stimulant agent
KW  -  acceleration time index; adult; analysis of variance; Article; blood flow velocity; blowout score; blowout time; clinical evaluation; comparative study; controlled study; correlation analysis; eating habit; eye blood flow; falling rate; female; flow acceleration index; fluctuation; human; human experiment; laser speckle flowgraphy; male; mean blur rate; non invasive procedure; normal human; optic disk; optic nerve; priority journal; pulse wave; resistive index; rising rate; skew; statistical analysis; waveform; blood flow; drug effect; laser Doppler flowmetry; microcirculation; physiology; procedures; vascularization; young adult
KW  -  Adult; Blood Flow Velocity; Caffeine; Central Nervous System Stimulants; Female; Healthy Volunteers; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Optic Disk; Regional Blood Flow; Young Adult
ID  - scholars10057
N2  - Purpose: To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between non-habitual and habitual groups due to caffeine intake. Method: This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result: There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the non-habitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion: The experiment results demonstrated caffeine does modulate OBF significantly and response differently in non-habitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
IS  - 9
VL  - 256
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048041837&doi=10.1007%2fs00417-018-4030-9&partnerID=40&md5=1ffa58ed24d03e9498a5ebcb8fec2559
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology
A1  - Ismail, A.
A1  - Bhatti, M.S.
A1  - Faye, I.
A1  - Lu, C.K.
A1  - Laude, A.
A1  - Tang, T.B.
Y1  - 2018///
ER  -