eprintid: 10052
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/00/52
datestamp: 2023-11-09 16:36:41
lastmod: 2023-11-09 16:36:41
status_changed: 2023-11-09 16:30:28
type: article
metadata_visibility: show
creators_name: Ong, C.C.
creators_name: Gopinath, S.C.B.
creators_name: Rebecca, L.W.X.
creators_name: Perumal, V.
creators_name: Lakshmipriya, T.
creators_name: Saheed, M.S.M.
title: Diagnosing human blood clotting deficiency
ispublished: pub
keywords: antibody; aptamer; blood clotting factor 9; bovine serum albumin; ethanolamine; gold nanoparticle; macrogol; thrombin; blood clotting factor 9; thrombin, antigen binding; blood clotting factor deficiency; conformational transition; electrochemical detection; evanescent field coupled waveguide mode sensor; hemophilia A; hemophilia B; human; impedance spectroscopy; partial thromboplastin time; Review; spectrofluorometry; surface plasmon resonance; animal; blood; blood clotting disorder; chemistry; metabolism; procedures, Animals; Aptamers, Nucleotide; Blood Coagulation Disorders; Factor IX; Humans; Surface Plasmon Resonance; Thrombin
note: cited By 32
abstract: There are different clotting factors present in blood, carries the clotting cascade and excessive bleeding may cause a deficiency in the clotting Diagnosis of this deficiency in clotting drastically reduces the potential fatality. For enabling a sensor to detect the clotting factors, suitable probes such as antibody and aptamer have been used to capture these targets on the sensing surface. Two major clotting factors were widely studied for the diagnosis of clotting deficiency, which includes factor IX and thrombin. In addition, factor IX is considered as the substitute for heparin and the prothrombotic associated with the increased thrombin generation are taking into account their prevalence. The biosensors, surface plasmon resonance, evanescent-field-coupled waveguide-mode sensor, metal-enhanced PicoGreen fluorescence and electrochemical aptasensor were well-documented and improvements have been made for high-performance sensing. We overviewed detecting factor IX and thrombin using these biosensors, for the potential application in medical diagnosis. © 2018 Elsevier B.V.
date: 2018
publisher: Elsevier B.V.
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048716262&doi=10.1016%2fj.ijbiomac.2018.05.084&partnerID=40&md5=54595d2b100028262bdbd41535d60001
id_number: 10.1016/j.ijbiomac.2018.05.084
full_text_status: none
publication: International Journal of Biological Macromolecules
volume: 116
pagerange: 765-773
refereed: TRUE
issn: 01418130
citation:   Ong, C.C. and Gopinath, S.C.B. and Rebecca, L.W.X. and Perumal, V. and Lakshmipriya, T. and Saheed, M.S.M.  (2018) Diagnosing human blood clotting deficiency.  International Journal of Biological Macromolecules, 116.  pp. 765-773.  ISSN 01418130