As a lot of people spend their time indoor, indoor thermal comfort will affect the performance of the occupants in terms of health, comfort and productivity. This paper aims to investigate the thermal comfort of an office building constructed using low cost materials in tropical climate condition. That has been achieved by investigating the PMV using the CBE thermal comfort tool in the post-graduate office building in the solar research site in UTP. The experimental measurements have been conducted at two different cases; without ventilation and with air-conditioned in the office building. The thermal comfort of the office building is assessed by using the ASHRAE thermal sensation scale. Results have demonstrated that the office room without ventilation is hot and not suitable for occupants to work at such thermal environment. Thermal comfort of the room with air-conditioning is warm and is slightly better than the room without ventilation as the PMV has been improved by around 60. However, the acceptable thermal comfort level in the low-cost material office building is yet to be achieved. © 2018 The Authors, published by EDP Sciences.