The use of vane-less diffuser with large diffusion angle has shown a setback in the diffusion process of high temperature working fluids. The hot gas flow was characterized as a jet-like flow. This paper presents problem, encountered practically, using a vane-less diffuser with large diffusion angle and how the problem is solved by CFD simulation. The investigated thermal diffuser has a length of 0.3 m, an inlet to outlet crosssectional area ratio of 1:25 and diffusion angle of 115.44o. To resolve the jet-like flow problem and poor distribution of the flow temperature at the diffuser outlet, the study suggested the use of guide-vanes into the diffuser. The study employed CFD simulation by ANSYS-FLUENT software to analyze the flow and thermal process in the diffuser. Three different shapes of guide vanes; block-shaped, oval-shaped and airfoil-shaped were considered in this study and at different vanes diffusion angles, as well as vane-less case, which was adopted as the bench mark case. The simulation results of the velocity, temperature and pressure at the diffuser outlet were compared for all cases. It was found that the guide vanes with symmetrical airfoil profile provided the best performance with most uniform distribution at the outlet of the diffuser. Also, the airfoil-shaped guide vanes resulted in lower pressure losses compared to the block-shaped and oval-shaped guide vanes. According to the analysis results, the diffuser was redesigned to improve the diffusion and temperature distribution across the diffuser outlet. © 2018 The Authors, published by EDP Sciences.