Ethylene glycol and propylene glycol are commonly used as thermal liquids in solar flat-plate collectors (FPCs). They are utilized as base liquid as well as for improving the stability of nanofluids in FPCs. The objective of the present paper is to introduce a renewable-derived bio glycol for use as base liquid in FPCs. The effect of base ratio (BR) of different glycol products on the performance of a conventional FPC and a nanofluidladen FPC is investigated in this paper to determine its suitability. MATLAB programming was employed for modeling the performance of the FPC operating with copper and cerium oxide nanomaterials. The results show that 20:80 bio glycol/water mixture is capable of enhancing the FPC's energetic efficiency up to 72.1 which is higher than with either ethylene glycol and propylene glycol. The energy efficiency of a glycol-based nanofluid-filled FPC decreases with the base ratio of all three glycol products. Since bio glycol is a non-toxic and safe product, it can be utilized as a safe and environmentally-friend antifreeze and base liquid in nanofluid-filled FPCs. © 2018 The Authors, published by EDP Sciences.