Ionic liquids and amino acids are recently introduced as novel gas hydrate inhibitors. However, they show less inhibition impact as compared to commercial gas hydrate inhibitors. Therefore, testing the combined effort of some of the best performed ionic liquids and amino acids in open literature would be necessary to understand and probably increase their inhibition performance. In this study, the synergic thermodynamic inhibition effect of 1-Ethyl-3-methy-limidazolium chloride (EMIM-Cl) + glycine on methane hydrate is reported. A sapphire hydrate cell and the T-cycle method was used within the pressures and temperatures ranges of 3 - 11 MPa and 274 - 286 K, respectively. Surprisingly the inhibition preformation of the mixed 1-Ethyl-3-methy-limidazolium chloride + glycine at 10 wt. was found to be slightly less than pure 1-Ethyl- 3-methy-limidazolium chloride and glycine at same concentration, the results were all found to generally be in the same range with their pure systems (pure 1-Ethyl-3-methy-limidazolium chloride and glycine at 10wt) . This behaviour is probably due to the colligative properties of 1- Ethyl-3-methy-limidazolium chloride and glycine, thus, causing a relatively equal inhibition impact. © Published under licence by IOP Publishing Ltd.