There are several CO 2 removal technologies currently applied in the commercial and production scale. One of the potential technologies currently being evaluated for offshore CO 2 separation is Centrifugal Fluid Separation technology, specifically Supersonic Gas Separation (SGS). It is potentially better than the conventional solutions such as membrane in terms of CAPEX, hydrocarbon losses, footprint, tonnage and power requirement. However, the stringent requirement of cryogenic temperature and high pressure of its feed requires a robust feed conditioning process plant. There are limited studies on the simulation and control design which are crucial to test the stability and dynamic responses of the feed conditioning plant. This paper investigates the optimal regulatory plant-wide control strategy for the feed conditioning plant subjected by various disturbances in temperature, pressure and feed CO 2 composition. © Published under licence by IOP Publishing Ltd.