The design and prototyping of a power amplifier for a two-way mobile radio is reported here. Mobile radios usually have transmitter whose power output ranges from 1 W to 50 W. Design of transmitter line-up for mobile radio involves the design of appropriate matching network for driver and power amplifier. The power and voltage control of these devices are equally important. Designing a mobile radio transmitter is regarded tricky due to difficulty in getting a robust transmitter that is stable with minimum oscillation. In this work, the design of a power amplifier with appropriate matching network for application in 216 MHz to 247 MHz is attempted using Advanced Design Simulator (ADS) and prototyped. ©2006 IEEE.