Healthcare providers in Malaysia are facing the challenges linking clinical administrative processes to ensure that an effective collaboration and efficient delivery of care are in place. The challenge is influenced by the state of the current health information technology (HIT) infrastructure and hospital information and management systems (HIMS) deployed across hospitals in Malaysia that are typically confined within a particular healthcare provider without any sort of sharing and integration across other healthcare service providers and its associates. With these challenges identified, the study attempts to examine the factors associating the perceived transformation impact within the context of the healthcare sector in Malaysia. The findings of this study involves a survey being carried out with a total 564 participant's with the responses being screened with IBM SPSS 20.0. Structural equation modelling (SEM) using AMOS 20.0 was adopted to test all latent factors of the research model and it resulted in a relatively good fit. The overall empirical findings as a result from this study suggests that healthcare providers can be relieved supporting complex in house IT infrastructures by leveraging on the proposed private cloud national health information exchange. Copyright © 2016 Inderscience Enterprises Ltd.