The oil and gas sector plays a vital role in the economic development of Malaysia. The transportation of oil and gas product is a sensitive issue because a minor negligence of a tanker truck driver can cause a serious accident of heavy loss and fatality. To address this issue, the study of oil and gas truck drivers� Fatigue is very important because most of the transportation activities depend on them. Further, the psychological risk factors (personality traits, behaviors and work stress) have a high impact on drivers� fatigue. The annual report has been taken from Malaysian Institute of Road Safety Research. The report has identified the fatalities rate among heavy vehicle drivers. Several fatal crashes� results show the high fatalities rate in Malaysia. The concepts of mental fatigue, physical fatigue, task-related fatigue and socioeconomic impacts of drivers� fatigue are discussed in this study. In conclusion, the proposed methodology and future recommendations are presented. © 2016, Econjournals. All rights reserved.