Granulation is commonly used as an enlargement process of particles produce granules with desirable characteristics and functionality. Granulation process transforms fine powders into free-flowing, dust-free granules with the presence of liquid binder at certain operating conditions. The main focus of this research is on seeded granulation of detergent powders, a new phenomenon of granulation in which a layer of fine powders surround the coarse particle. This is already proven for calcium carbonate (Rahmanian et al., 2011). Here, detergent granules were produced in a 5 L high shear Cyclomix granulator using different fine/coarse powder ratio (1/3, 1, 3) and different binder ratio of 10 , 20 and 30 . The granules were then characterized for their particle size distribution, strength and structure. It was found that a high percentage (70 wt. ) of granules in the desired size range between 125 - 1,000 ?m were produced using the powder ratio of 1/3 and a binder content of 10 . Low mean crushing strength (3.0 N) with a narrow distribution was obtained using this condition. Structure characterization of the detergent granules produced in the granulator shows that consistent seeded granule structures are produced under the optimum process and formulation conditions of 1/3 powder ratio with 10 binder. Copyright © 2016, AIDIC Servizi S.r.l.