This paper presents an overview of preliminary research study of Information Communication and Technology (ICT) in small and medium size of clinics of healthcare industry in Malaysia. A combination of qualitative and quantitative research method will be implemented in research study. An early conceptual Clinic Information System (CIS) success framework is presented and proposed as to assist in evaluating and implementing CIS in small, medium and enterprise (SME) clinics. The conceptual framework is developed using hybrid approach based on various prominent information success models Therefore, the proposed framework of SME CIS Success Model will be helpful to the SME clinics management to have better understanding in regard to the success of information system implementation. Future research activities and plan are also outlined in the paper. © 2010 ACM.