Studying biologically inspired systems had a great interest in few last years. Artificial networks, evolutionary computation, DNA , and artificial immune systems are of the researcher interest which can be . The human immune system (HIS) is a of molecules, cells, and organs which has to perform several tasks; imperfect , distributed detection, adaptability, and of diversity, recognition, learning, acquisition, generalization, and . New computational techniques are developed basing on the immune system , seeking to solve several engineering problems. Moreover, mobile ad hoc networks (MANETs) have no clear line of defense and no infrastructure; therefore, the known security used for cabled networks might not work . A security architecture based on both and multi-agent paradigm is presented.,second response, and self recovery, are the hallmarks of the proposed security model which places emphasis on high nodes mobility. ©2008 IEEE.