Scientists recently turned to the immune system as a wealthy source for inspiration. The network security is one of the most interested fields that represent fertile ground to apply the immunity. This approach endeavoring to inspire a bio- protocol to resolve a part of the hybrid networks problems. Hybrid may consist of wireless and non-wireless components, hybrid protocols, nodes. Each (the cabled and the wireless) has its own architecture and protocols, involve in some same features and different in others; and here comes the attention by one of the most important types of networks to be dealt with. A variety of threats necessarily means variety ways of considerations. The present approach is following the same concept of the innate body immune system. © 2008 IEEE.