The increasing number of zoonosis coupled with the frequency of occurrences has made the need to study zoonosis a major concern among researchers. It is important to have a single system that is able to analyze the relationship between different diseases in emergence zoonosis. However, the development of such system presents a daunting and yet to be explored task. Earlier work has proposed a 3-stage framework to develop a zoonosis emerging system. This paper reports on the selection and constructions process of zoonosis domains and their relationship rules as a preliminary work of this zoonosis emerging system. A set of data collected from 35 zoonotic diseases was used for this purpose. Preliminary analysis of this data collection exposed a domain dataset distribution. Further examination of the domain distribution revealed important information dataset about each individual domain. This information is useful and could be used to predict zoonosis-risk evidence based on domain dataset. © 2008 IEEE.