Biologically - inspired computer security has various techniques to solve the problems that facing computer networks security, such as immune system, diversity, danger theory, virus Epidemiology and non-representational approaches. Immune Systems are fairly complex with some unique schemes and are thus a rich source of concepts, which are applicable to a variety of problems. In this paper a new framework together with a set of paradigms for adaptive immune virtual layers implemented by multi-mobile agents based active monitoring of network systems is proposed. Multi-mobile agents combine features of adaptation, self defending and self monitoring of human immune system, that works in parallel with decentralizes control. Adaptive immune virtual layers system could be implemented by Kernel -assisted mobile agents (processes) that migrate between computers and search for a specific abnormal behavior, and take necessary actions: monitoring each other, detecting attacks, eliminating, circulating, and replicating themselves. © 2008 IEEE.