The authors propose an overview framework for the design and implementation of online rule-based Expert Systems for Islamic medication. This Online Islamic Medication Expert Systems (OIMES) focuses on physical and inner illnesses. The knowledge base of the proposed ES shall contain exhaustively the types of illness or sickness together with their related cures or treatments/therapies, obtained exclusively from the Quran and Hadith. Extensive research and study are to be conducted to ensure that the expert system is able to provide the most suitable treatment with reference to the relevant verses cited in Quran or Hadith. These verses come together with their related 'actions' (bodily actions/gestures or some acts) to be performed by the patient to treat a particular illness/sickness. These verses and the instructions for the 'actions' are to be displayed unambiguously on the computer screen. The online platform provides the advantage to the patient for advising treatment practically anytime and anywhere as long as the computer and internet facilities exist. Patient does not need to make appointment to see an expert for a therapy. She/He may try this alternative method provided the sickness is not that very critical. © 2008 IEEE.