The work presented in this paper investigates the degradation effect of flow maldistribution on the thermal and hydraulic performance of a heat exchanger. A new mathematical model is derived based on Taylor series expansion to describe the contribution of each of the four statistical moments of distribution on the degradation problem. It is found that the first two moments, i.e. mean and standard deviation, have the highest effect on the performance degradation. Subsequent higher moments will give declining degradation effects until the fourth moment, kurtosis, which has no significant effect. Maldistribution with low standard deviation and high positive skew will give low thermal deteriorations, though a distribution with negative skew is preferred for low hydraulic performance losses. The design of the heat exchanger could be modified to give these favourable moments which would minimize the degradation effects of the maldistribution. Consequently, any effort to modify the flow distribution profile should be focused on optimizing the first three moments. © 2010 Elsevier Masson SAS. All rights reserved.