Injection Mold Thermal Management is a critical issue in plastic injection molding process and has major effects on production cycle times that is directly linked with cost and also has effects on part quality. For this reason, cooling system design has great significance for plastic products industry by injection molding. It is crucial not only to reduce molding cycle time but also it considerably affects the productivity and quality of the product. The cooling channels in injection molding have circular cross section due to the conventional manufacturing technique of drilling. In Rapid Prototyping and Tooling techniques of fabricating conformal cooling channels, the channel cross section is again circular. In circular channel, there can be a problem that the distance from the edges of channel to the cavity is not constant and it is variable even for conformal channels. This can give problem of not having even heat dissipation. In this study, injection mold designing and thermal simulations were performed and comparison is presented between molds having cooling channels of circular cross section with mold with profiled cross section channels. Thermal analysis and simulations can effectively predict the performance of circular channels as compared to profiled channels. Some concepts are also presented for the manufacturing of molds with circular and profiled channels with the use of metal filled epoxies.