Integrating photovoltaic (PV) systems into power grids is essential for mitigating power losses and improving grid stability, especially under conditions of significant time-varying loads. This research examines the optimization of the placement and sizing of PV systems to minimize power losses under these dynamic conditions, contrasting with previous studies that utilized constant load models. The research employs the Coyote Optimization Algorithm (COA) using real-world load and PV generation data, focusing on industrial, residential, and commercial loads. The results indicate that COA reduces power losses by 13.45, 20.03 and 31.27 under industrial, residential and commercial loads respectively compared to the base case PV system. The optimal PV location was consistently found to be at bus 6, while the optimal PV size varied across load types. Additionally, there is a notable improvement in voltage profiles across all load types. This research offers valuable insights into developing efficient and reliable grid-connected PV systems, highlighting the potential of COA in enhancing system performance through load-specific optimization strategies. © 2024 IEEE.