Gas hydrates pose serious threats to pipeline safety and can have a significant impact on the economy of gas production operations. Conventional gas hydrate inhibitors can be categorized as; thermodynamic hydrate inhibitors (THIs) and kinetic hydrate inhibitors (KHIs). THIs are volatile organic solvents that decrease the quality of the hydrocarbons, whereas KHI are hazardous polymers that cause stern safety obligations. Additionally, conventional THIs and KHIs could only induce single functional inhibition, either THI or KHI. In this book chapter, recent developments in the area of gas hydrate inhibitors have been discussed. To overcome these limitations of the conventional inhibitors, more economic, accessible, and safe-to-environment chemicals are studied. These studies discover the field of ionic liquids and amino acids to be the future of the gas hydrate inhibitors. Specially, the ammonium-based ionic liquids with their multifunctional capabilities will be a breakthrough in this area. © 2024 Elsevier Inc. All rights reserved.