Tall buildings have emerged in popularity as a solution for accommodating swift urban population growth, economic expansion, and spatial constraints. However, as sustainability takes precedence in urban development, the performance and optimization of tall buildings have assumed critical research significance. Wind loads predominantly dictate the parameters for the design and optimization of these structures, mandating a wind-responsive approach to assess structural behaviors. This challenge is compounded by contemporary architectural trends favoring asymmetrical shapes and intricate geometries, where external form crucially influences wind-induced motion on tall buildings. This paper firstly undertakes a review study based on prior research works to investigate the main challenges and associated impediments in the pursuit of optimizing asymmetrical tall buildings for designs that are sustainable, safe, and economically viable. In response, a conceptual design workflow is developed and proposed by utilizing advanced computational technology to address the array of challenges inherent in designing and optimizing asymmetrical tall buildings. Hence, this research work lays the groundwork for further exploration and broader application to facilitate its implementation for the effective realization of asymmetrical tall buildings within industrial practices. © 2024 IEEE.