DBrain is a project to support dementia-affected people. One of the targeted deliverables from the DBrain project is a grid system that will be utilized for diagnosis, therapeutics, and treatment of dementia disease. This paper will present a study to provide a collaborative environment through a single portal interface to access all resources from multiple institutions in a grid. Users, including researchers and scientists, only need to log into the portal. They don't need to log into each of individual resources to use them. The portal will also support a variety of grid middleware platforms. It will serve as interface for a specific-purpose grid infrastructure, called BioGrid. This type of grid is used to support computational applications in bioinformatics and biomedical sciences. © 2011 Springer-Verlag.