This study aimed to analyze the opinions and emotions of Malaysians towards the COVID-19 vaccination program, as expressed on Twitter. By collecting data from the Twitter network and utilizing the machine learning life cycle technique. The results show that Malaysians have a mostly neutral viewpoint of the COVID-19 vaccination, with an accuracy score of 93, an F1-score of 94, a recall measurement of 94, and a precision measure of 93. These findings emphasize the significance of understanding public sentiment and perception towards crucial issues such as the COVID-19 vaccine and can be utilized to support healthcare professionals, policymakers, and the public in making informed decisions regarding the COVID-19 vaccination program. © 2024, Institute of Advanced Engineering and Science. All rights reserved.